Modelling and Dosimetry for Alpha-Particle Therapy

Alpha - Particle Emitter Therapy : Overview , Current Status , and Dosimetry

MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have ...

IL13RA2 targeted alpha particle therapy against glioblastomas

Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted ...

alpha-Particle emitters in radioimmunotherapy: new and welcome challenges to medical internal dosimetry.

Over the past decade, there has been progressively stronger interest in the use of a-particle emitters for radioimmunotherapy (1–6). With proper localization of the labeled antibody, the high linear energy transfer of a-particles provides a correspondingly high probability of mitotic cell kill when compared with an equivalent number of cellular traversals by lower linear energy transfer b-parti...

Analytical expressions for water-to-air stopping-power ratios relevant for accurate dosimetry in particle therapy.

In particle therapy, knowledge of the stopping-power ratio (STPR) of the ion beam for water and air is necessary for accurate ionization chamber dosimetry. Earlier work has investigated the STPR for pristine carbon ion beams, but here we expand the calculations to a range of ions (1 ≤ z ≤ 18) as well as spread-out Bragg peaks (SOBPs) and provide a theoretical in-depth study with a special focus...